New Research from Division of Biomedical Sciences & Biochemistry, Research School of Biology, Australian National University; Sydney, Australia

With our history of providing the most innovative research of light emitting diode or HEALS technology we feel an obligation to share the latest published paper entitled: "Gene and noncoding RNA regulation underlying photoreceptor protection: microarray study of dietary antioxidant saffron and photobiomodulation in rat retina" Riccardo Natoli, Yuan Zhu, Krisztina Valter, Silvia Bisti, Janis Eells, Jonathan Stone

Conclusion: Given alone, saffron and (more prominently) PBM (Photobiomodulation) both regulated significant numbers of genes and ncRNAs. Given before retinal exposure to damaging light, thus while exerting their neuroprotective action, they regulated much larger numbers of entities, among which ncRNAs were prominent. Further, the downregulation of known genes and of ncRNAs was prominent in the protective actions of both neuroprotectants. These comparisons provide an overview of gene expression induced by two neuroprotectants and provide a basis for the more focused study of their mechanisms.

PBM seems to act through at least two pathways, by reducing inflammation and by reducing oxidative damage. Future investigation of the ncRNAs regulated by PBM and saffron could reveal further clues to their mechanism of protection